A new study published in the journal PLoS Medicine found people with several risk factors for obesity were more likely to put on weight.

The study, involving 41,000 people, showed having one or more risk factors accounted for added pounds among thinner people. The same factors accounted for even more pounds among people who were obese.

“Appetite and body weight are tightly regulated. We think as one becomes more overweight, the tight regulation of body weight and appetite starts to fall apart, and weight becomes more susceptible to these risk factors,” said study author Paul Williams of the Lawrence Berkeley National Laboratory.

Risk factors included inactivity and poor diet choice.